Ethyl cyanoacetate → 2-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)acetonitrile

HRID 1394169ノート

反応式

HRID 1394169 の反応式
[CH2:1]([NH:3][C:4]1[CH:9]=[CH:8][N:7]=[CH:6][C:5]=1[NH2:10])[CH3:2].[C:11]([CH2:13][C:14](OCC)=O)#[N:12]>>[CH2:1]([N:3]1[C:4]2[CH:9]=[CH:8][N:7]=[CH:6][C:5]=2[N:10]=[C:14]1[CH2:13][C:11]#[N:12])[CH3:2]

参加物

3

反応物 2

HCID 7764Ethyl cyanoacetateHCID 120363924-N-ethylpyridine-3,4-diamine

生成物 1

HCID 468352622-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)acetonitrile収率 37.3%

実験手順

The product from Step 2 (500 mg, 3.6 mmole) and ethyl cyanoacetate (620 mg, 5.5 mmol) were heated together at 190° C. for 20 minutes. After cooling to room temperature, the residue was purified by column chromatography eluting with 10% methanol in ethyl acetate to afford the title compound (250 mg, 37%); MS (ES+) m/e 187 [M+H]+.

後処理

  1. customthe residue was purified by column chromatography
  2. washeluting with 10% methanol in ethyl acetate

出典と根拠

ORDレコード
ord-ebcc45573a904d45bc1b6c093e6679a4
出典データセット
uspto-grants-2008_03
特許番号
US07348339B2

反応ノート

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