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Methyl chloroformate → (+/-)-Methyl (5-chloro-2,3-dihydronaphtho[1,2-b]furan-2-yl)methylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl chloroformate | HCID 6586 | — |
| 反応物 | Methyl p-toluenesulfonate | HCID 6645 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | (+/-)-(5-Chloro-2,3-dihydronaphtho[1,2-b]furan-2-yl)methylamine | HCID 11436234 | — |
| 生成物 | (+/-)-Methyl (5-chloro-2,3-dihydronaphtho[1,2-b]furan-2-yl)methylcarbamate | HCID 86598556 | 93% |
反応手順
Treatment of (±)-(5-chloro-2,3-dihydronaphtho[1,2-b]furan-2-yl)methylamine (2.60 g, 9.62 mmol) with diisopropylethylamine (3.73 g, 28.85 mmol) and methyl chloroformate (1.36 g, 9.62 mmol) generally according to the procedure described for Intermediate 7 afforded 2.60 g (93%) of (±)-methyl (5-chloro-2,3-dihydronaphtho[1,2-b]furan-2-yl)methylcarbamate as a white solid. mp 128-130° C.; Anal. calcd. for C15H14ClNO3: C, 61.76; H, 4.84; N, 4.80. Found: C, 61.43; H, 4.87; N, 4.68.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728155B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-89a55ca56b2f4c6cad993fd79d796618 |
| 出典メモ | uspto-grants-2010_06 |