Sodium Methoxide → 2,4-Dimethoxy-5-nitropyridine

HRID 1394224

反応式

HRID 1394224 の反応式
Cl[C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([N+:10]([O-:12])=[O:11])=[CH:4][N:3]=1.[CH3:13][O-:14].[Na+]>CO>[CH3:13][O:14][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([N+:10]([O-:12])=[O:11])=[CH:4][N:3]=1

参加物

4

反応物 2

HCID 10942334Sodium MethoxideHCID 441196732-Chloro-4-methoxy-5-nitropyridine

生成物 1

HCID 513584872,4-Dimethoxy-5-nitropyridine収率 98%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of the product of Step 2 (950 mg, 5 mmol), sodium methoxide (695 mg, 12.5 mmol) in methanol (10 ml) was heated at reflux for 2 hours. After cooling the solvent was removed in vacuo and the residue partitioned between ethyl acetate and water. The organic phase was washed with water and brine, dried and evaporated in vacuo to give the title compound (900 mg, 98%). MS (ES+) m/e 185 [M+H]+.

後処理

  1. temperatureat reflux for 2 hours
  2. temperatureAfter cooling the solvent
  3. customwas removed in vacuo
  4. customthe residue partitioned between ethyl acetate and water
  5. washThe organic phase was washed with water and brine
  6. customdried
  7. customevaporated in vacuo

出典と根拠

ORDレコード
ord-e370cd43028748c99eff0354a3683c90
出典データセット
uspto-grants-2008_03
特許番号
US07348339B2

関連ノート

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