4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride → n-[(4-Dimethylamino-4-phenylcyclohexylcarbamoyl)methyl]-3-(1h-indol-3-yl)butyramide

HRID 1394238ノート

反応式

HRID 1394238 の反応式
[NH2:1][CH2:2][C:3]([NH:5][CH:6]1[CH2:11][CH2:10][C:9]([N:18]([CH3:20])[CH3:19])([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:8][CH2:7]1)=[O:4].[Cl-].C[O:23]C1N=C(OC)N=C([N+]2(C)CCOCC2)N=1.[NH:39]1[C:47]2[C:42](=[CH:43][CH:44]=[CH:45][CH:46]=2)[C:41]([CH:48]([CH2:52][CH3:53])[C:49](O)=O)=[CH:40]1>CO>[CH3:19][N:18]([CH3:20])[C:9]1([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:10][CH2:11][CH:6]([NH:5][C:3]([CH2:2][NH:1][C:53](=[O:23])[CH2:52][CH:48]([C:41]2[C:42]3[C:47](=[CH:46][CH:45]=[CH:44][CH:43]=3)[NH:39][CH:40]=2)[CH3:49])=[O:4])[CH2:7][CH2:8]1

参加物

5

反応物 3

HCID 27340594-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chlorideHCID 122300802-(1H-indol-3-yl)butanoic acidHCID 692169152-Amino-n-(4-dimethylamino-4-phenylcyclohexyl)acetamide

生成物 1

HCID 69216438n-[(4-Dimethylamino-4-phenylcyclohexylcarbamoyl)methyl]-3-(1h-indol-3-yl)butyramide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The more nonpolar diastereomer of 2-amino-N-(4-dimethylamino-4-phenylcyclohexyl)acetamide (276 mg, 1.0 mmole) and 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (415 mg, 1.5 mmole) were added to a solution of indol-3-yl-butyric acid (203 mg, 1.0 mmole) in MeOH and stirred for 24 h at room temperature. Working up was performed by removing MeOH by distillation. The batch was re-dissolved with water, adjusted to pH 11 with 5M NaOH and extracted with ethyl acetate. The organic phase was dried with Na2SO4 and evaporated. The more nonpolar amide was obtained as a colorless oil in a yield of 450 mg (98%).

後処理

  1. customby removing MeOH
  2. distillationby distillation
  3. dissolutionThe batch was re-dissolved with water
  4. extractionextracted with ethyl acetate
  5. dry with materialThe organic phase was dried with Na2SO4
  6. customevaporated

出典と根拠

ORDレコード
ord-7953475dcd6b47b8b464e0048a0943cc
出典データセット
uspto-grants-2008_03
特許番号
US07348354B2

反応ノート

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