N-t-butoxycarbonyl-4-(4-fluorobenzylidene)piperidine → 4-(4-Fluoro-benzyl)-piperidine-1-carboxylic acid tert-butyl ester

HRID 1394292ノート

反応式

HRID 1394292 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=[CH:14][C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO.[C].[Pd]>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

参加物

4

反応物 1

HCID 22676694N-t-butoxycarbonyl-4-(4-fluorobenzylidene)piperidine

生成物 1

HCID 226766794-(4-Fluoro-benzyl)-piperidine-1-carboxylic acid tert-butyl ester収率 84.3%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

1-tert-Butoxycarbonyl-4-(4-fluorobenzylidene)piperidine (47.0 g) was dissolved in methanol (450 ml). To the solution was added 10% palladium carbon (water content: 50%, 4.7 g), and the mixture was subjected to catalytic hydrogenation reaction for 5 hours. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure to give 1-tert-butoxycarbonyl-4-(4-fluorobenzyl)piperidine (39.9 g).

後処理

  1. customthe mixture was subjected to catalytic hydrogenation reaction for 5 hours
  2. filtrationThe catalyst was filtered off
  3. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-9b027a0af0a6494db26112c3c3d7572a
出典データセット
uspto-grants-2008_03
特許番号
US07348324B2

反応ノート

読み込み中…