Hydrochloric Acid → 4-[(4-Fluorophenyl)methyl]piperidine hydrochloride

HRID 1394293ノート

反応式

HRID 1394293 の反応式
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22]>C(OCC)(=O)C>[ClH:22].[F:21][C:18]1[CH:17]=[CH:16][C:15]([CH2:14][CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[CH:20][CH:19]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 226766794-(4-Fluoro-benzyl)-piperidine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 170394924-[(4-Fluorophenyl)methyl]piperidine hydrochloride

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

To 1-tert-butoxycarbonyl-4-(4-fluorobenzyl)piperidine (39.9 g) was added 4N-hydrogen chloride in ethyl acetate (100 ml), and the solution was stirred at room temperature for 1 hour. The reaction mixture was concentrated under reduced pressure, and to the concentrate was added diethyl ether. The resulting precipitates were collected by filtration, washed with diethyl ether, and dried under reduced pressure to give the titled compound (30.1 g).

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. additionto the concentrate was added diethyl ether
  3. customThe resulting precipitates
  4. filtrationwere collected by filtration
  5. washwashed with diethyl ether
  6. customdried under reduced pressure

出典と根拠

ORDレコード
ord-3b2221855024433592a4772758a93c93
出典データセット
uspto-grants-2008_03
特許番号
US07348324B2

反応ノート

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