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Triphenylphosphine → (+/-)-(4-chloro-3,6,7,8-tetrahydro-2H-indeno[4,5-b]furan-2-yl)methyl 4-methylbenzenesulfonate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | Diisopropyl azodicarboxylate | HCID 5363146 | — |
| 反応物 | (+/-)-3-(6-chloro-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-2-hydroxypropyl 4-methylbenzenesulfonate | HCID 86598559 | — |
| 生成物 | (+/-)-(4-chloro-3,6,7,8-tetrahydro-2H-indeno[4,5-b]furan-2-yl)methyl 4-methylbenzenesulfonate | HCID 86598560 | 91% |
反応手順
Treatment of (±)-3-(6-chloro-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-2-hydroxypropyl 4-methylbenzenesulfonate (4.7 g, 0.012 mol) with triphenylphosphine (4.64 g, 0.018 mol) and diisopropylazodicarboxylate (3.57 g, 0.018 mol) generally according to the procedure described for Intermediate 5 gave 4.09 g (91%) of (±)-(4-chloro-3,6,7,8-tetrahydro-2H-indeno[4,5-b]furan-2-yl)methyl 4-methylbenzenesulfonate as a white solid. mp 95-97° C.; Anal. calcd. for C19H19ClO4S: C, 60.23; H, 5.05. Found: C, 60.12; H, 4.97.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728155B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-714700fe06cf405db662baa55aff6c87 |
| 出典メモ | uspto-grants-2010_06 |