Formic Acid → 3-Nitro-4-formamidobenzaldehyde

HRID 1395564

反応式

HRID 1395564 の反応式
[CH:1]([OH:3])=O.[N+:4]([C:7]1[CH:8]=[C:9]([CH:12]=[CH:13][C:14]=1[NH2:15])[CH:10]=[O:11])([O-:6])=[O:5].C(OC(=O)C)(=O)C>O>[N+:4]([C:7]1[CH:8]=[C:9]([CH:12]=[CH:13][C:14]=1[NH:15][CH:1]=[O:3])[CH:10]=[O:11])([O-:6])=[O:5]

参加物

5

反応物 3

HCID 284Formic AcidHCID 7918Acetic AnhydrideHCID 132377034-Amino-3-nitrobenzaldehyde

生成物 1

HCID 203400463-Nitro-4-formamidobenzaldehyde収率 80%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To 56.6 ml (1.50 mol) of HCOOH was added 24.9 g (150 mmol) of 3-nitro-4-aminobenzaldehyde. The solution was heated to reflux, 28.4 ml (300 mmol) of acetic anhydride was added dropwise and the solution was refluxed for 30 minutes. The resulting suspension was cooled and poured into 400 ml of cold H2O with rapid stirring. The product was filtered, air dried, and recrystallized from isopropanol to yield 23.2 g (80%) of 3-nitro-4-formamidobenzaldehyde as a bright yellow powder: melting point=183°-191°.

後処理

  1. temperatureThe solution was heated
  2. temperatureto reflux
  3. temperaturethe solution was refluxed for 30 minutes
  4. temperatureThe resulting suspension was cooled
  5. filtrationThe product was filtered
  6. customair dried
  7. customrecrystallized from isopropanol

出典と根拠

ORDレコード
ord-5031d5b89010401baaa69e62662dd643
出典データセット
uspto-grants-1980_05
特許番号
US04204069

関連ノート

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