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1-(Bromomethyl)-3-phenoxybenzene → m-Phenoxybenzyl 2-isopropyl-4-(o-chlorophenyl)-3-butenoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(Bromomethyl)-3-phenoxybenzene | HCID 94544 | — |
| 反応物 | 2-(2-Chlorophenyl)acetaldehyde | HCID 11378624 | — |
| 反応物 | HCID 53812558 | HCID 53812558 | — |
| 反応物 | 2-Isopropyl-4-(o-chlorophenyl)-3-butenoic acid | HCID 54528296 | — |
| 反応物 | KOH MeOH Water | HCID 86591755 | — |
| 生成物 | m-Phenoxybenzyl 2-isopropyl-4-(o-chlorophenyl)-3-butenoate | HCID 54240396 | — |
反応手順
The process of Example 3 is repeated using o-chlorophenylacetaldehyde to prepare ethyl 2-isopropyl-4-(o-chlorophenyl)-3-butenoate, which is hydrolyzed (potassium hydroxide-water/methanol) to the acid, 2-isopropyl-4-(o-chlorophenyl)-3-butenoic acid. The acid is reacted with m-phenoxybenzyl bromide as in Example 1 to yield m-phenoxybenzyl 2-isopropyl-4-(o-chlorophenyl)-3-butenoate. MS m/e 420 (M+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04204071 |
| 出典データセット | uspto-grants-1980_05 |
| ORD ID | ord-cea0b473752c47b5ad7e966fcd44a7ba |
| 出典メモ | uspto-grants-1980_05 |