1-(Bromomethyl)-3-phenoxybenzene → HCID 54240396、化合物

HRID 1395607

反応式

HRID 1395607 の反応式
ClC1C=CC=CC=1CC=O.[CH:11]([CH:14]([CH:20]=[CH:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[Cl:28])[C:15]([O:17][CH2:18][CH3:19])=[O:16])([CH3:13])[CH3:12].[OH-].[K+].O.CO.C(C(C=CC1C=CC=CC=1Cl)C(O)=O)(C)C.[O:50]([C:57]1[CH:58]=C([CH:62]=[CH:63][CH:64]=1)CBr)[C:51]1[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=1>>[CH:11]([CH:14]([CH:20]=[CH:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[Cl:28])[C:15]([O:17][CH2:18][C:19]1[CH:62]=[CH:63][CH:64]=[C:57]([O:50][C:51]2[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=2)[CH:58]=1)=[O:16])([CH3:12])[CH3:13]

参加物

6

反応物 5

HCID 945441-(Bromomethyl)-3-phenoxybenzeneHCID 113786242-(2-Chlorophenyl)acetaldehydeHCID 53812558HCID 53812558、化合物HCID 545282962-Isopropyl-4-(o-chlorophenyl)-3-butenoic acidHCID 86591755KOH MeOH Water

生成物 1

HCID 54240396HCID 54240396、化合物

実験手順

The process of Example 3 is repeated using o-chlorophenylacetaldehyde to prepare ethyl 2-isopropyl-4-(o-chlorophenyl)-3-butenoate, which is hydrolyzed (potassium hydroxide-water/methanol) to the acid, 2-isopropyl-4-(o-chlorophenyl)-3-butenoic acid. The acid is reacted with m-phenoxybenzyl bromide as in Example 1 to yield m-phenoxybenzyl 2-isopropyl-4-(o-chlorophenyl)-3-butenoate. MS m/e 420 (M+).

出典と根拠

ORDレコード
ord-cea0b473752c47b5ad7e966fcd44a7ba
出典データセット
uspto-grants-1980_05
特許番号
US04204071

関連ノート

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