Ethyl 5-phenylbenzofuran-2-carboxylate → 5-Phenyl-2-benzofurancarboxylic acid

HRID 1395678ノート

反応式

HRID 1395678 の反応式
[C:1]1([C:7]2[CH:8]=[CH:9][C:10]3[O:14][C:13]([C:15]([O:17]CC)=[O:16])=[CH:12][C:11]=3[CH:20]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>[OH-].[K+]>[C:1]1([C:7]2[CH:8]=[CH:9][C:10]3[O:14][C:13]([C:15]([OH:17])=[O:16])=[CH:12][C:11]=3[CH:20]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

3

反応物 1

HCID 20329644Ethyl 5-phenylbenzofuran-2-carboxylate

生成物 1

HCID 129909085-Phenyl-2-benzofurancarboxylic acid

試薬・触媒・溶媒 1

HCID 14797Potassium Hydroxide溶媒

実験手順

A mixture of 1.3 g of Compound 1B and 50 ml of 10% alcoholic potassium hydroxide was refluxed for 4 hours. The solvent was evaporated under reduced pressure and the residue was washed with ether and dissolved in water. The basic solution was acidified with dilute hydrochloric acid and extracted with ether. The ether layer was extracted with dilute sodium bicarbonate solution. The aqueous solution was re-acidified with dilute hydrochloric acid and extracted with ether. The ether extract was dried (Na2SO4) and concentrated under reduced pressure. The residue was crystallized from ethanol to give 5-phenyl-2-benzofurancarboxylic acid (1C), as white solid, mp: 220°-221° C.

後処理

  1. temperaturewas refluxed for 4 hours
  2. customThe solvent was evaporated under reduced pressure
  3. washthe residue was washed with ether
  4. dissolutiondissolved in water
  5. extractionextracted with ether
  6. extractionThe ether layer was extracted with dilute sodium bicarbonate solution
  7. extractionextracted with ether
  8. extractionThe ether extract
  9. dry with materialwas dried (Na2SO4)
  10. concentrationconcentrated under reduced pressure
  11. customThe residue was crystallized from ethanol

出典と根拠

ORDレコード
ord-160d1a7db5d44aff9b3e04e942fc8931
出典データセット
uspto-grants-1980_05
特許番号
US04205080

反応ノート

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