Ammonia → HCID 86689801、化合物
反応式
[Cl:1][C:2]1[N:7]=[N:6][C:5]([C:8](OCC)=[O:9])=[C:4]([NH:13][C:14]2[CH:19]=[C:18]([CH3:20])[CH:17]=[C:16]([CH2:21][CH2:22][CH3:23])[N:15]=2)[CH:3]=1.CO.[NH3:26]>>[Cl:1][C:2]1[N:7]=[N:6][C:5]([C:8]([NH2:26])=[O:9])=[C:4]([NH:13][C:14]2[CH:19]=[C:18]([CH3:20])[CH:17]=[C:16]([CH2:21][CH2:22][CH3:23])[N:15]=2)[CH:3]=1参加物
4
反応条件
- 温度
- 40 °C
実験手順
A mixture of ethyl 6-chloro-4-(4-methyl-6-propylpyridin-2-ylamino)pyridazine-3-carboxylate (147 mg, 439 μmol) in ammonia in methanol (7 N, 6.27 mL, 43.9 mmol) was heated to 40° C. for 16 h. The mixture was concentrated in vacuo to give 6-chloro-4-(4-methyl-6-propylpyridin-2-ylamino)pyridazine-3-carboxamide (134 mg, 438 μmol, 100%) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.88 (s, 1H), 9.16 (s, 1H), 8.82 (s, 1H), 8.18 (s, 1H), 6.83 (s, 1H), 6.76 (s, 1H), 2.69 (t, J=7.3 Hz, 2H), 2.29 (s, 3H), 1.76 (m, 1H), 0.95 (t, J=7.3 Hz, 3H); MS (EI/CI) m/z: 305.9 [M+H].