3-(4-Fluorophenoxy)propionic acid → Dimethyl 2-(3-(4-fluorophenoxy)propanamido)malonate

HRID 1396689

反応式

HRID 1396689 の反応式
[NH2:1][CH:2]([C:7]([O:9][CH3:10])=[O:8])[C:3]([O:5][CH3:6])=[O:4].[F:11][C:12]1[CH:23]=[CH:22][C:15]([O:16][CH2:17][CH2:18][C:19](O)=[O:20])=[CH:14][CH:13]=1>>[F:11][C:12]1[CH:23]=[CH:22][C:15]([O:16][CH2:17][CH2:18][C:19]([NH:1][CH:2]([C:7]([O:9][CH3:10])=[O:8])[C:3]([O:5][CH3:6])=[O:4])=[O:20])=[CH:14][CH:13]=1

参加物

3

反応物 2

HCID 740993-(4-Fluorophenoxy)propionic acidHCID 437601Dimethyl aminomalonate hydrochloride

生成物 1

HCID 50941576Dimethyl 2-(3-(4-fluorophenoxy)propanamido)malonate収率 80%

実験手順

This compound was synthesized from dimethyl aminomalonate according to the procedure for the preparation of example 2 using 3-(4-fluorophenoxy)propionic acid. The crude residue was purified by flash chromatography on silica (CH2Cl2/MeOH 50:1) to yield the title compound as a white solid (80%).

後処理

  1. customThe crude residue was purified by flash chromatography on silica (CH2Cl2/MeOH 50:1)

出典と根拠

ORDレコード
ord-65a150ca252845d0888cf704465dbc65
出典データセット
uspto-grants-2014_12
特許番号
US08901132B2

関連ノート

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