Hydrochloric Acid → (3R)-3-(Cyclopentylmethyl)-4-oxo-4-{5-[(2-pyrimidinylamino)carbonyl]-4,5-dihydro-1H-pyrazol-1-yl}butanoic acid

HRID 1396967ノート

反応式

HRID 1396967 の反応式
[CH:1]1([CH2:6][C@@H:7]([C:16](=[O:31])[N:17]2[CH:21]([C:22]([NH:24][C:25]3[N:30]=[CH:29][CH:28]=[CH:27][N:26]=3)=[O:23])[CH2:20][CH:19]=[N:18]2)[CH2:8][C:9]([O:11]C(C)(C)C)=[O:10])[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl>O1CCOCC1>[CH:1]1([CH2:6][C@@H:7]([C:16](=[O:31])[N:17]2[CH:21]([C:22]([NH:24][C:25]3[N:26]=[CH:27][CH:28]=[CH:29][N:30]=3)=[O:23])[CH2:20][CH:19]=[N:18]2)[CH2:8][C:9]([OH:11])=[O:10])[CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 682880681,1-dimethylethyl (3R)-3-(cyclopentylmethyl)-4-oxo-4-{5-[(2-pyrimidinylamino)carbonyl]-4,5-dihydro-1H-pyrazol-1-yl}butanoate

生成物 1

HCID 68287994(3R)-3-(Cyclopentylmethyl)-4-oxo-4-{5-[(2-pyrimidinylamino)carbonyl]-4,5-dihydro-1H-pyrazol-1-yl}butanoic acid収率 100%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

To a solution of 1,1-dimethylethyl (3R)-3-(cyclopentylmethyl)-4-oxo-4-{5-[(2-pyrimidinylamino)carbonyl]-4,5-dihydro-1H-pyrazol-1-yl}butanoate (0.21 g, 0.49 mmol) in 1,4-dioxane (10.0 mL) was added 4.0 M hydrochloric acid in 1,4-dioxane (6.11 mL, 24.4 mmol) at room temperature. The reaction mixture was stirred overnight. The solvent was then removed by reduced pressure to afford the crude product (−100% yield), which was used directly in the next step. MS: 374 ([M+H]+).

後処理

  1. customThe solvent was then removed by reduced pressure

出典と根拠

ORDレコード
ord-dfb397d09b894b7d874dbb510deb8967
出典データセット
uspto-grants-2014_12
特許番号
US08901119B2

反応ノート

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