Boronic Acid → [3,3'-Bithiophene]-5-carbaldehyde

反応式

B(O)O.Br[C:5]1[CH:6]=[C:7]([CH:10]=[O:11])[S:8][CH:9]=1.[S:12]1[CH:16]=[CH:15][C:14](B(O)O)=[CH:13]1>>[S:8]1[C:7]([CH:10]=[O:11])=[CH:6][C:5]([C:14]2[CH:15]=[CH:16][S:12][CH:13]=2)=[CH:9]1

参加物

反応物 3

HCID 61668Boronic Acid

HCID 877924-Bromothiophene-2-carbaldehyde

HCID 581760Thiophene-3-boronic acid

生成物 1

HCID 16218061[3,3'-Bithiophene]-5-carbaldehyde

実験手順

[3,3′-bithiophene]-5-carbaldehyde was prepared using the general boronic acid coupling procedure with 4-bromothiophene-2-carbaldehyde and thiophen-3-ylboronic acid (56 mg, 102 mg theoretical, 54.9%). LC-MS m/z 195 (M+1).

出典と根拠

ORDレコード: ord-fd9ad87ec7a24e0eba456bd77b4da529
出典データセット: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08901145B2

反応ノート

読み込み中…