関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Lipoamide | HCID 863 | — |
| 反応物 | Vinyl hexanoate | HCID 76451 | — |
| 反応物 | ethyl 3-hydroxy-3,6-dihydro-2H-pyran-4-carboxylate | HCID 67329448 | — |
| 溶媒 | Diisopropyl Ether | HCID 7914 | — |
| 生成物 | ethyl (3R)-3-hydroxy-3,6-dihydro-2H-pyran-4-carboxylate | HCID 67328954 | 50.3% |
反応手順
To a solution (380 mL) of ethyl 3-hydroxy-3,6-dihydro-2H-pyran-4-carboxylate (91.2 g) in diisopropyl ether were added vinyl hexanoate (150 mL) and Lipozyme IM (4.8 g). The reaction mixture was stirred at 35° C. for 24 hr and the insoluble material was filtered off. The obtained filtrate was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography (hexane/ethyl acetate=6:1→1:1) to give the title compound (45.9 g, 50%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08901171B2 |
|---|
| 出典データセット | uspto-grants-2014_12 |
|---|
| ORD ID | ord-0895eaf6cad8426ba6232aa5b156271a |
|---|
| 出典メモ | uspto-grants-2014_12 |
|---|
