Sodium triacetoxyborohydride → 1-(4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)-N-(3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzyl)methanamine

HRID 1397208ノート

反応式

HRID 1397208 の反応式
C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].[F:15][C:16]([F:31])([F:30])[C:17]1[O:21][N:20]=[C:19]([C:22]2[CH:23]=[C:24]([CH:27]=[CH:28][CH:29]=2)[CH:25]=O)[N:18]=1.[C:32]1([C:38]2[N:39]=[C:40]([C:43]3([CH2:49][NH2:50])[CH2:48][CH2:47][O:46][CH2:45][CH2:44]3)[S:41][CH:42]=2)[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>ClC(Cl)C>[C:32]1([C:38]2[N:39]=[C:40]([C:43]3([CH2:49][NH:50][CH2:25][C:24]4[CH:27]=[CH:28][CH:29]=[C:22]([C:19]5[N:18]=[C:17]([C:16]([F:31])([F:30])[F:15])[O:21][N:20]=5)[CH:23]=4)[CH2:44][CH2:45][O:46][CH2:47][CH2:48]3)[S:41][CH:42]=2)[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1

参加物

5

反応物 3

HCID 5049666Sodium triacetoxyborohydrideHCID 185454733-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzaldehydeHCID 67322930(4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methanamine

生成物 1

HCID 699499611-(4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)-N-(3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzyl)methanamine収率 22%

試薬・触媒・溶媒 1

HCID 63651,1-Dichloroethane溶媒

実験手順

Sodium triacetoxy borohydride (200 mg, 0.9 mmol) was added to a solution of 3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzaldehyde (140 mg, 0.6 mmol) and (4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methanamine (170 mg, 0.6 mmol) in dry dichloroethane (20 mL) at 0° C. under nitrogen atmosphere and stirred at room temperature for 8 h. The reaction mixture was carefully quenched with 10% NaHCO3 solution and extracted with EtOAc. The organic layer was washed with brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude product was purified by column chromatography (silica 60-120 mesh, eluent 20-25% EtOAc in petroleum ether) to get 1-(4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)-N-(3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzyl)methanamine (65 mg, yield 22%): 1H NMR (400 MHz, CDCl3) δ 7.98 (m, 2H), 7.89 (d, J=7.6 Hz, 2H), 7.48 (s, 1H), 7.46-7.27 (m, 5H), 3.86-3.81 (m, 4H), 3.69-3.64 (m, 2H), 2.91 (s, 2H), 2.36 (m, 2H), 2.03-1.97 (ddd, J=13.7 Hz, 9.7 Hz, 4 Hz, 2H). MS (ESI) m/z: Calculated for C25H23F3N4O2S: 500.15. found: 501.0 (M−H)−.

後処理

  1. customThe reaction mixture was carefully quenched with 10% NaHCO3 solution
  2. extractionextracted with EtOAc
  3. washThe organic layer was washed with brine
  4. dry with materialdried over anhydrous Na2SO4
  5. concentrationconcentrated under reduced pressure
  6. customThe crude product was purified by column chromatography (silica 60-120 mesh, eluent 20-25% EtOAc in petroleum ether)

出典と根拠

ORDレコード
ord-a867969a2e7c4e708ae72814a29386a4
出典データセット
uspto-grants-2014_12
特許番号
US08901156B2

反応ノート

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