Bromoacetic Acid → HCID 57464135、化合物
反応式
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][N:3]=1.[Br:11][CH2:12][C:13]([OH:15])=[O:14]>CN(C=O)C>[Br-:11].[C:6]([C:5]1[CH:9]=[CH:10][C:2]([CH3:1])=[N+:3]([CH2:12][C:13]([OH:15])=[O:14])[CH:4]=1)(=[O:7])[NH2:8]参加物
4
実験手順
A solution of 6-methyl nicotinamide (400 mg, 2.94 mmol, 1.0 eq) and bromoacetic acid (408 mg, 2.94 mmol, 1.0 eq) in DMF (10 mL) was stirred at room temperature for 6 days. The reaction mixture was monitored by LCMS. Solvent was then evaporated and the crude product was purified by preparative HPLC to afford 136 mg of the expected compound.
後処理
- customSolvent was then evaporated
- customthe crude product was purified by preparative HPLC
出典と根拠
- ORDレコード
- ord-12cf5a9093164299af0c44d3399bcefa
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08901293B2
反応ノート
読み込み中…