Potassium Fluoride → 2-(5-Fluoropyridin-2-yl)but-3-yn-2-ol

HRID 1398515ノート

反応式

HRID 1398515 の反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([OH:16])([C:10]#[C:11][Si](C)(C)C)[CH3:9])=[N:6][CH:7]=1.[F-].[K+]>CO.C(OCC)(=O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([OH:16])([C:10]#[CH:11])[CH3:9])=[N:6][CH:7]=1

参加物

5

反応物 2

HCID 522689Potassium FluorideHCID 681818642-(5-Fluoropyridin-2-yl)-4-(trimethylsilyl)but-3-yn-2-ol

生成物 1

HCID 831252472-(5-Fluoropyridin-2-yl)but-3-yn-2-ol収率 86.3%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A solution of 2-(5-fluoropyridin-2-yl)-4-(trimethylsilyl)but-3-yn-2-ol (1 g, 4.21 mmol) and potassium fluoride (987 mg, 16.99 mmol) in methanol (10 mL) was stirred for 2 hr at 50° C. The resulting solution was diluted with ethyl acetate (20 mL) and the solid material was removed by filtration. The filtrate was concentrated in vacuo to give 600 mg (86%) of the title compound as yellow oil: LC-MS: m/z=+166 (M+H)+.

後処理

  1. customthe solid material was removed by filtration
  2. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-aa0eb5df16264d5db4862e46b8e4ea23
出典データセット
uspto-grants-2014_12
特許番号
US08901313B2

反応ノート

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