4-[6-Bromo-2-(oxetan-3-yloxy)-1,3-benzodiazol-1-yl]pyrimidin-2-amine → 4-[6-bromo-2-(2-methoxyethoxy)-1H-1,3-benzodiazol-1-yl]pyrimidin-2-amine

関与物質

反応手順

The title compound was prepared by the procedure described for the synthesis of 4-[6-bromo-2-(oxetan-3-yloxy)-1H-1,3-benzodiazol-1-yl]pyrimidin-2-amine, by replacing oxetan-3-ol with 2-methoxyethanol: 1H NMR (500 MHz, DMSO) delta 3.31 (3H, s), 3.83-3.72 (2 H, m), 4.77-4.61 (2H, m), 7.02 (1H, d, J=5.5 Hz), 7.12 (2H, s), 7.48-7.33 (2H, m), 8.38 (1H, d, J=5.5 Hz), 8.45 (1H, d, J=1.8 Hz); LC-MS: m/z=+364/366 (M+H)+.

情報源と証拠