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4-[6-Bromo-2-(oxetan-3-yloxy)-1,3-benzodiazol-1-yl]pyrimidin-2-amine → 4-[6-Iodo-2-(2-methoxyethoxy)-1,3-benzodiazol-1-yl]pyrimidin-2-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-[6-Bromo-2-(oxetan-3-yloxy)-1,3-benzodiazol-1-yl]pyrimidin-2-amine | HCID 68181588 | — |
| 反応物 | 4-[6-iodo-2-(trichloromethyl)-1H-1,3-benzodiazol-1-yl]pyrimidin-2-amine | HCID 68181943 | — |
| 溶媒 | 2-Methoxyethanol | HCID 8019 | — |
| 生成物 | 4-[6-Iodo-2-(2-methoxyethoxy)-1,3-benzodiazol-1-yl]pyrimidin-2-amine | HCID 68181597 | — |
反応手順
The title compound was prepared by the procedure described for the synthesis of 4-[6-bromo-2-(oxetan-3-yloxy)-1H-1,3-benzodiazol-1-yl]pyrimidin-2-amine by reacting 4-[6-iodo-2-(trichloromethyl)-1H-1,3-benzodiazol-1-yl]pyrimidin-2-amine with 2-methoxyethanol: LC-MS: m/z=+412 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08901313B2 |
| 出典データセット | uspto-grants-2014_12 |
| ORD ID | ord-e7b5da260bac4021909c7a224afd213c |
| 出典メモ | uspto-grants-2014_12 |