4-[6-Iodo-2-(2-methoxyethoxy)-1,3-benzodiazol-1-yl]pyrimidin-2-amine → (2R)-4-[1-(2-aminopyrimidin-4-yl)-2-(2-methoxyethoxy)-1H-1,3-benzodiazol-6-yl]-2-(5-methyl-1,2,4-oxadiazol-3-yl)but-3-yn-2-ol

関与物質

反応手順

The title compound was prepared by the procedure described for the synthesis of 4-[1-(2-aminopyrimidin-4-yl)-2-(2-methoxyethoxy)-1H-1,3-benzodiazol-6-yl]-2-(pyrimidin-2-yl)but-3-yn-2-ol (Example 121-c), by reacting 4-[6-iodo-2-(2-methoxyethoxy)-1,3-benzodiazol-1-yl]pyrimidin-2-amine with (2R)-2-(5-methyl-1,2,4-oxadiazol-3-yl)but-3-yn-2-ol: 1H NMR (500 MHz, DMSO) delta 1.84 (3H, s), 2.61 (3H, s), 3.31 (3H, s), 3.84-3.69 (2H, m), 4.76-4.63 (2H, m), 6.66 (1H, s), 6.97 (1H, d, J=5.5 Hz), 7.09 (2H, s), 7.28 (1H, dd, J=8.2, 1.5 Hz), 7.46 (1H, d, J=8.2 Hz), 8.18 (1H, d, J=1.0 Hz), 8.39 (1H, d, J=5.5 Hz); LC-MS: m/z=+436.1 (M+H)+.

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