HCID 68736952、化合物 → HCID 86632926、化合物

HRID 1398944ノート

反応式

HRID 1398944 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH2:8])[C:3]=1[NH:9][CH2:10][CH2:11][CH2:12][NH:13][C:14](=[O:20])[O:15][C:16]([CH3:19])([CH3:18])[CH3:17].Cl.[Cl:22][C:23]1[CH:28]=[C:27]([Cl:29])[CH:26]=[CH:25][C:24]=1[CH:30]([OH:35])[C:31](=N)OC>C(O)C.O>[NH2:1][C:2]1[C:3]2[N:9]([CH2:10][CH2:11][CH2:12][NH:13][C:14](=[O:20])[O:15][C:16]([CH3:17])([CH3:19])[CH3:18])[C:31]([CH:30]([C:24]3[CH:25]=[CH:26][C:27]([Cl:29])=[CH:28][C:23]=3[Cl:22])[OH:35])=[N:8][C:4]=2[CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 68736952HCID 68736952、化合物HCID 86632925HCID 86632925、化合物

生成物 1

HCID 86632926HCID 86632926、化合物収率 85%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

To a stirred solution of tert-butyl {3-[(2,6-diaminophenyl)amino]propyl}carbamate (5.47 g, 19.5 mmol) in ethanol (39 mL) was added methyl 2-(2,4-dichlorophenyl)-2-hydroxyethanimidoate hydrochloride (5.80 g, 19.5 mmol) at room temperature. After 14 h, the reaction mixture was diluted with water. The resultant precipitate was collected by filtration and washed with water and ethyl acetate to give the title compound as a colorless solid (7.67 g, 16.5 mmol, 85%).

後処理

  1. filtrationThe resultant precipitate was collected by filtration
  2. washwashed with water and ethyl acetate

出典と根拠

ORDレコード
ord-40ab4a4dc89d4b649e9cc914538cd748
出典データセット
uspto-grants-2014_12
特許番号
US08901141B2

反応ノート

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