2-Bromo-5-propylthiophene → 2-(3,5-Difluoro-4'-ethylbiphenyl-4-yl)-5-propylthiophene

反応式

[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[C:13]([F:15])[C:12](B(O)O)=[C:11]([F:19])[CH:10]=2)=[CH:5][CH:4]=1)[CH3:2].Br[C:21]1[S:22][C:23]([CH2:26][CH2:27][CH3:28])=[CH:24][CH:25]=1>>[F:19][C:11]1[CH:10]=[C:9]([C:6]2[CH:7]=[CH:8][C:3]([CH2:1][CH3:2])=[CH:4][CH:5]=2)[CH:14]=[C:13]([F:15])[C:12]=1[C:21]1[S:22][C:23]([CH2:26][CH2:27][CH3:28])=[CH:24][CH:25]=1

参加物

反応物 2

HCID 218019042-Bromo-5-propylthiophene

HCID 666260714'-Ethyl-3,5-difluoro-4-biphenylboronic acid

生成物 1

HCID 580284372-(3,5-Difluoro-4'-ethylbiphenyl-4-yl)-5-propylthiophene

実験手順

The compound 2-(3,5-difluoro-4′-ethylbiphenyl-4-yl)-5-propylthiophene (PUS-2-3) is prepared analogously to Example 2 from 4′-ethyl-3,5-difluoro-4-biphenylboronic acid and 2-bromo-5-propylthiophene.

出典と根拠

ORDレコード: ord-9d9195cfc2764dea945cad878daebea6
出典データセット: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08906261B2

反応ノート

読み込み中…