Glycine → 2-(2,6-Dinitrobenzamido)acetic acid

関与物質

反応手順

The reaction of 2,6-dinitrobenzoyl chloride (prepared from 2,6-dinitrobenzoic acid, 1.2 g and SOCl2, 20 mL) with glycine (530 mg, 7.075 mmol) in the presence of Na2CO3 (749 mg, 7.075 mmol) as described in intermediate 2 gave the title compound as an off-white color solid (1.2 g, 80%), mp 210-212° C. 1H NMR (400 MHz, DMSO-d6): δ 12.76 (1H, s), 9.22 (1H, t, J=5.0 Hz), 8.45 (2H, d, J=8.4 Hz), 7.93 (1H, t, J=8.4 Hz), 3.98 (2H, d, J=5.2 Hz); LC-MS (negative ion mode): m/z 268 (M−H)−.

情報源と証拠