Water → HCID 49863419、化合物

HRID 1399505ノート

反応式

HRID 1399505 の反応式
O.[CH3:2][C:3]([O:8]/[N:9]=[C:10](\[C:17]([NH:19][C@@H:20]1[C:23](=[O:24])[N:22]2[C:25]([C:44]([OH:46])=[O:45])=[C:26]([CH2:29][N+:30]3[N:34]([CH3:35])[C:33]([NH2:36])=[C:32]([NH:37][C:38]([NH:40][CH2:41][CH2:42][NH2:43])=[O:39])[CH:31]=3)[CH2:27][S:28][C@H:21]12)=[O:18])/[C:11]1[N:12]=[C:13]([NH2:16])[S:14][N:15]=1)([C:5]([O-:7])=[O:6])[CH3:4].[S:47](=[O:51])(=[O:50])([OH:49])[OH:48]>C(O)(C)C>[CH3:4][C:3]([O:8]/[N:9]=[C:10](\[C:17]([NH:19][C@@H:20]1[C:23](=[O:24])[N:22]2[C:25]([C:44]([OH:46])=[O:45])=[C:26]([CH2:29][N+:30]3[N:34]([CH3:35])[C:33]([NH2:36])=[C:32]([NH:37][C:38]([NH:40][CH2:41][CH2:42][NH2:43])=[O:39])[CH:31]=3)[CH2:27][S:28][C@H:21]12)=[O:18])/[C:11]1[N:12]=[C:13]([NH2:16])[S:14][N:15]=1)([C:5]([O-:7])=[O:6])[CH3:2].[OH:50][S:47]([OH:51])(=[O:49])=[O:48]

参加物

5

反応物 3

HCID 962WaterHCID 1118Sulfuric AcidHCID 714579552-[(Z)-[2-[[(6R,7R)-3-[[5-amino-4-(2-aminoethylcarbamoylamino)-1-methylpyrazol-2-ium-2-yl]methyl]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl]amino]-1-(5-amino-1,2,4-thiadiazol-3-yl)-2-oxoethylidene]amino]oxy-2-methylpropanoate2 回

生成物 1

HCID 49863419HCID 49863419、化合物

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

A ceftolozane sulfate composition can be obtained by a process comprising the steps of: (a) forming a solution comprising water, 72-100 g/L ceftolozane active and 1.5-2.95 molar equivalents of sulfuric acid to ceftolozane; (b) combining the solution from step (a) with 20-40 volumes of isopropyl alcohol added to the solution over 0.5-8 hours to obtain solid ceftolozane sulfate; and (c) isolating the solid ceftolozane sulfate composition from the solution.

後処理

  1. customforming a solution
  2. additionadded to the solution over 0.5-8 hours

出典と根拠

ORDレコード
ord-7142d3ffdcd2470bb2cbd61dbed5cbf6
出典データセット
uspto-grants-2014_12
特許番号
US08906898B1

反応ノート

読み込み中…