Piperidine-1-carboxamidine → 2-(6-Oxo-4-phenyl-2-(piperidin-1-yl)-1,6-dihydropyrimidin-5-yl)pentanoic acid

HRID 1399730ノート

反応式

HRID 1399730 の反応式
[N:1]1([C:7](=[NH:9])[NH2:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:10]([CH:18]([CH:24]([CH2:30][CH2:31][CH3:32])[C:25]([O:27]CC)=[O:26])[C:19](OCC)=[O:20])(=O)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C[O-].[Na+]>CO>[O:20]=[C:19]1[NH:8][C:7]([N:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)=[N:9][C:10]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[C:18]1[CH:24]([CH2:30][CH2:31][CH3:32])[C:25]([OH:27])=[O:26]

参加物

5

反応物 3

HCID 205051Piperidine-1-carboxamidineHCID 10942334Sodium MethoxideHCID 66955320Diethyl 2-benzoyl-3-propylsuccinate

生成物 1

HCID 1363461692-(6-Oxo-4-phenyl-2-(piperidin-1-yl)-1,6-dihydropyrimidin-5-yl)pentanoic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

To a solution of piperidine-1-carboximidamide (dimer complexated with H2SO4) (0.6 g; 4.71 mmol) and diethyl 2-benzoyl-3-propylsuccinate (1.51 g; 4.71 mmol) in methanol (5 mL) was slowly added a solution of sodium methoxide in methanol (25% w:w) (2.16 mL; 9.43 mmol) and the reaction was heated to reflux for 21 h. The volatiles were removed under reduced pressure and the crude residue was used as such in the next reaction.

後処理

  1. temperaturethe reaction was heated
  2. temperatureto reflux for 21 h
  3. customThe volatiles were removed under reduced pressure
  4. customsuch in the next reaction

出典と根拠

ORDレコード
ord-0ff40907276142138d4dc7b53ed5a47b
出典データセット
uspto-grants-2014_12
特許番号
US08906906B2

反応ノート

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