Piperidine-1-carboxamidine → 2-(4-Ethyl-6-oxo-2-(piperidin-1-yl)-1,6-dihydropyrimidin-5-yl)pentanoic acid

HRID 1399736ノート

反応式

HRID 1399736 の反応式
[N:1]1([C:7](=[NH:9])[NH2:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:10]([CH:14]([CH:20]([CH2:26][CH2:27][CH3:28])[C:21](OCC)=[O:22])[C:15]([O:17]CC)=[O:16])(=O)[CH2:11][CH3:12].C[O-].[Na+]>CO>[CH2:27]([C:26]1[N:9]=[C:7]([N:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[NH:8][C:21](=[O:22])[C:20]=1[CH:14]([CH2:10][CH2:11][CH3:12])[C:15]([OH:17])=[O:16])[CH3:28]

参加物

5

反応物 3

HCID 205051Piperidine-1-carboxamidineHCID 10942334Sodium MethoxideHCID 86665656Diethyl 2-propionyl-3-propylsuccinate

生成物 1

HCID 1363461602-(4-Ethyl-6-oxo-2-(piperidin-1-yl)-1,6-dihydropyrimidin-5-yl)pentanoic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

To a solution of piperidine-1-carboximidamide (dimer complexated with H2SO4) (1 g; 7.86 mmol) and diethyl 2-propionyl-3-propylsuccinate (2.14 g; 7.86 mmol) in methanol (8 mL) was slowly added a solution of sodium methoxide in methanol (25% w:w) (3.60 mL; 15.72 mmol) and the reaction was heated under reflux for 18 h. The mixture was concentrated under reduced pressure and the curde residue was used as such in the next reaction.

後処理

  1. temperaturethe reaction was heated
  2. temperatureunder reflux for 18 h
  3. concentrationThe mixture was concentrated under reduced pressure
  4. customsuch in the next reaction

出典と根拠

ORDレコード
ord-70610a653ff64ff98d8e9671db5dfcd4
出典データセット
uspto-grants-2014_12
特許番号
US08906906B2

反応ノート

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