Acetyl chloride → N-((5-bromopyridin-2-yl)methyl)acetamide
反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][NH2:9])=[N:6][CH:7]=1.CCN(CC)CC.[C:17](Cl)([CH3:19])=[O:18]>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][NH:9][C:17](=[O:18])[CH3:19])=[N:6][CH:7]=1参加物
5
実験手順
To a solution of (5-bromopyridin-2-yl)methanamine (500 mg, 2.67 mmol) in DCM (10 mL) was added Et3N (405 mg, 4.0 mmol) and AcCl (250 mg, 3.18 mmol) at 0° C. The mixture was then warmed to room temperature for 2 h when the reaction was quenched with water and extracted with DCM. The organic layer was concentrated to give the crude product which was used in next step without further purification. (540 mg, Yield 90%). LCMS (m/z): 229.0 (M+1).
後処理
- customwas quenched with water
- extractionextracted with DCM
- concentrationThe organic layer was concentrated
出典と根拠
- ORDレコード
- ord-61566a28a7ad4e19a1fb7c3c32d8c3fc
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08906900B2
反応ノート
読み込み中…