HCID 86709753、化合物 → HCID 68152103、化合物
反応式
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[NH:12][CH2:13][CH2:14][NH:15]C(=O)OC(C)(C)C>C(OCC)C.Cl.O1CCOCC1>[Cl-:1].[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[NH:12][CH2:13][CH2:14][NH3+:15]参加物
5
反応条件
- 温度
- 0 °C
実験手順
To a cooled (0° C.) single necked flask containing a solution of tert-butyl {2-[(1-chloronaphthalen-2-yl)amino]ethyl}carbamate in 4 mL of ethyl ether, 5 mL of 4 M HCl solution in dioxane were added. The resulting mixture was stirred at room temperature for 7 h. The reaction mixture was concentrated under reduce pressure to afford 2-[(1-chloronaphthalen-2-yl)amino]ethanaminium chloride as a pink solid (92% yield) which was pure by TLC and NMR analysis.
後処理
- additionwere added
- concentrationThe reaction mixture was concentrated
出典と根拠
- ORDレコード
- ord-95b35fc76b3f4997b474a1a7b1b3ded9
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08906946B2
反応ノート
読み込み中…