関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | 1-(2-Hydroxy-1-naphthyl)ethan-1-one | HCID 68455 | — |
| 触媒 | Zinc | HCID 23994 | — |
| 触媒 | Mercuric Chloride | HCID 24085 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-Naphthol, 1-ethyl- | HCID 3014975 | 84.3% |
反応手順
A single neck round-bottom flask was charged with 2.3 g of zinc, 0.23 g of HgCl2 and 4 mL of water. Then 37% HCl (0.1 mL) was added and the mixture stirred for 5 minutes. After this, 3 mL of toluene and 3.4 mL of 37% HCl were added and finally 1 g (5.37 mmol) of 1-(2-hydroxynaphthalen-1-yl)ethanone was added portion wise. The resulting mixture was heated at 110° C. for 18 h. The phases were separated and the organic layer was dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo to afford 780 mg (84% yield) of 1-ethylnaphthalen-2-ol as brown solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08906946B2 |
|---|
| 出典データセット | uspto-grants-2014_12 |
|---|
| ORD ID | ord-2c3e26fb70f34b4fba43c97b6d55b38f |
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| 出典メモ | uspto-grants-2014_12 |
|---|
