Potassium Carbonate → HCID 68276186、化合物

HRID 1400312ノート

反応式

HRID 1400312 の反応式
[F:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[OH:12].C([O-])([O-])=O.[K+].[K+].Br[C:20]([F:31])([F:30])[C:21]([NH:23][CH2:24][C:25]1[O:26][CH:27]=[CH:28][CH:29]=1)=[O:22]>CC(C)=O.C(OCC)(=O)C>[F:31][C:20]([F:30])([O:12][C:3]1[CH:4]=[CH:5][C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2]=1[F:1])[C:21]([NH:23][CH2:24][C:25]1[O:26][CH:27]=[CH:28][CH:29]=1)=[O:22]

参加物

6

反応物 3

HCID 11430Potassium CarbonateHCID 110949481-fluoronaphthalen-2-olHCID 68276609HCID 68276609、化合物

生成物 1

HCID 68276186HCID 68276186、化合物収率 112.1%

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 8857Ethyl Acetate溶媒

反応条件

温度
40 °C

実験手順

To a solution of 1-fluoronaphthalen-2-ol (280 mg, 1.73 mmol) and K2CO3 (1.2 g, 8.65 mmol) in 10 mL of acetone, 2-bromo-2,2-difluoro-N-(furan-2-ylmethyl)acetamide (527 mg, 2.08 mmol) were added. The resulting mixture was stirred at 40° C. overnight. The reaction was cooled at room temperature, diluted with ethyl acetate (30 mL) and washed with water. The organic layer was dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo to afford 2,2-difluoro-2-[(1-fluoronaphthalen-2-yl)oxy]-N-(furan-2-ylmethyl)acetamide as red oil (650 mg) which was used in the next step without further purification.

後処理

  1. temperatureThe reaction was cooled at room temperature
  2. washwashed with water
  3. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-60a245fc14e544ed9572728abf6cc3e1
出典データセット
uspto-grants-2014_12
特許番号
US08906946B2

反応ノート

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