Toluene → 5-(2-Bromoethynyl)-2-methylpyridine
反応式
[Br:1][C:2](Br)=[CH:3][C:4]1[CH:5]=[CH:6][C:7]([CH3:10])=[N:8][CH:9]=1.CC(C)([O-])C.[K+].C1(C)C=CC=CC=1>O>[Br:1][C:2]#[C:3][C:4]1[CH:5]=[CH:6][C:7]([CH3:10])=[N:8][CH:9]=1参加物
5
反応条件
- 温度
- 80 °C
実験手順
A mixture of 5-(2,2-dibromovinyl)-2-methylpyridine (0.10.9 g, 0.00393 mol), potassium tertbutoxide (0.88 g, 0.00787 mol) and toluene (13 mL) were heated at 80° C. for 4 h. After completion of reaction, the reaction mixture was cooled to RT, diluted with water (15 mL), and extracted with EtOAc (3×50 mL). The organic layer was dried over anhydrous sodium sulfate and concentrated under reduce pressure to obtain product as a yellow oil (0.25 g, 32.4%).
後処理
- customAfter completion of reaction
- temperaturethe reaction mixture was cooled to RT
- extractionextracted with EtOAc (3×50 mL)
- dry with materialThe organic layer was dried over anhydrous sodium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-fa79c36261984a3e9aac9013499144c1
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08906925B2
反応ノート
読み込み中…