Toluene → HCID 59455074、化合物

HRID 1400610ノート

反応式

HRID 1400610 の反応式
[Br:1][C:2](Br)=[CH:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[C:6]([F:12])[CH:5]=1.CC(C)([O-])C.[K+].C1(C)C=CC=CC=1>O>[Br:1][C:2]#[C:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[C:6]([F:12])[CH:5]=1

参加物

5

反応物 3

HCID 1140TolueneHCID 23665647Potassium tert-butoxideHCID 594550774-(2,2-Dibromovinyl)-2-fluoro-1-methoxybenzene

生成物 1

HCID 59455074HCID 59455074、化合物収率 81.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

A mixture of 1-(2,2-dibromo-vinyl)-3-fluoro-4-methoxybenzene (0.5 g, 0.00161 mol), potassium tertbutoxide (0.36 g, 0.00322 mol) and toluene (6 mL) were heated at 80° C. for 4 h. After completion, the reaction mixture was cooled to RT, diluted with water (15 mL), and extracted with EtOAc (3×50 mL). The organic layer was dried over anhydrous sodium sulfate and concentrated under reduce pressure to obtain product as a yellow oil (0.3 g, 81%).

後処理

  1. temperatureAfter completion, the reaction mixture was cooled to RT
  2. extractionextracted with EtOAc (3×50 mL)
  3. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-acfbef9632954084bd9d371f62e710b6
出典データセット
uspto-grants-2014_12
特許番号
US08906925B2

反応ノート

読み込み中…