1-(4-(2-(5-((Azetidin-3-yloxy)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea → N-((6-(7-(6-(3-cyclopropylureido)pyridin-3-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)-2-hydroxy-N-(2-methoxyethyl)acetamide

HRID 1400933ノート

反応式

HRID 1400933 の反応式
N1CC(OCC2C=CC(C3SC4C(=NC=CC=4OC4C=CC(NC(NC5CC5)=O)=CC=4F)C=3)=NC=2)C1.C([O:40][CH2:41][C:42]([N:44]([CH2:49][C:50]1[CH:51]=[N:52][C:53]([C:56]2[S:64][C:63]3[C:58](=[N:59][CH:60]=[CH:61][C:62]=3[O:65][C:66]3[CH:67]=[N:68][C:69]([NH:72][C:73]([NH:75][CH:76]4[CH2:78][CH2:77]4)=[O:74])=[CH:70][CH:71]=3)[CH:57]=2)=[CH:54][CH:55]=1)[CH2:45][CH2:46][O:47][CH3:48])=[O:43])(=O)C>>[CH:76]1([NH:75][C:73](=[O:74])[NH:72][C:69]2[N:68]=[CH:67][C:66]([O:65][C:62]3[CH:61]=[CH:60][N:59]=[C:58]4[CH:57]=[C:56]([C:53]5[N:52]=[CH:51][C:50]([CH2:49][N:44]([CH2:45][CH2:46][O:47][CH3:48])[C:42](=[O:43])[CH2:41][OH:40])=[CH:55][CH:54]=5)[S:64][C:63]=34)=[CH:71][CH:70]=2)[CH2:77][CH2:78]1

参加物

3

反応物 2

HCID 674417991-(4-(2-(5-((Azetidin-3-yloxy)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylureaHCID 674421792-(((6-(7-(6-(3-Cyclopropylureido)pyridin-3-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)(2-methoxyethyl)amino)-2-oxoethyl acetate

生成物 1

HCID 67442923N-((6-(7-(6-(3-cyclopropylureido)pyridin-3-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)-2-hydroxy-N-(2-methoxyethyl)acetamide

実験手順

Compounds 411-412 (examples 260-261) were prepared in one step by reacting the amine precursor 401 (table 31), similarly to compound 30 (scheme 13). Compound 413 (example 262) was obtained similarly to compound 31 (scheme 13). Compounds 414-415 (examples 263-264) were prepared in two steps by reacting the corresponding amine precursors 402 (table 31) and 405 (scheme 76), similarly to compound 31 (scheme 13).

後処理

  1. customCompounds 411-412 (examples 260-261) were prepared in one step

出典と根拠

ORDレコード
ord-a3216e3e763e44e0bf44fe58708ef8fa
出典データセット
uspto-grants-2014_12
特許番号
US08906852B2

反応ノート

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