Water → tert-Butyl {4-[6-(2-fluorophenoxy)oxazolo[4,5-c]pyridin-2-yl]-2,6-dimethylphenoxy}acetate

HRID 1401113ノート

反応式

HRID 1401113 の反応式
C(=O)([O-])[O-].[K+].[K+].[F:7][C:8]1[CH:32]=[CH:31][CH:30]=[CH:29][C:9]=1[O:10][C:11]1[N:16]=[CH:15][C:14]2[N:17]=[C:18]([C:20]3[CH:25]=[C:24]([CH3:26])[C:23]([OH:27])=[C:22]([CH3:28])[CH:21]=3)[O:19][C:13]=2[CH:12]=1.Br[CH2:34][C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36].O>CN(C)C=O>[F:7][C:8]1[CH:32]=[CH:31][CH:30]=[CH:29][C:9]=1[O:10][C:11]1[N:16]=[CH:15][C:14]2[N:17]=[C:18]([C:20]3[CH:21]=[C:22]([CH3:28])[C:23]([O:27][CH2:34][C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36])=[C:24]([CH3:26])[CH:25]=3)[O:19][C:13]=2[CH:12]=1

参加物

6

反応物 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 79177tert-Butyl bromoacetateHCID 1364132394-[6-(2-Fluorophenoxy)oxazolo[4,5-c]pyridin-2-yl]-2,6-dimethylphenol

生成物 1

HCID 71186150tert-Butyl {4-[6-(2-fluorophenoxy)oxazolo[4,5-c]pyridin-2-yl]-2,6-dimethylphenoxy}acetate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

110 mg of potassium carbonate were added to a solution of 70 mg of 4-[6-(2-fluorophenoxy)oxazolo[4,5-c]pyridin-2-yl]-2,6-dimethylphenol in 1 ml of dimethylformamide, and 51 mg of tert-butyl bromoacetate were then added. The mixture was stirred at room temperature for 16 h. The reaction mixture was then added to water and extracted twice with ethyl acetate. The collected organic phases were dried and concentrated. This gave 93 mg (100%) of the title compound, which was reacted further without any further purification.

後処理

  1. additionwere then added
  2. extractionextracted twice with ethyl acetate
  3. customThe collected organic phases were dried
  4. concentrationconcentrated
  5. customThis gave 93 mg (100%) of the title compound, which was reacted further without any further purification

出典と根拠

ORDレコード
ord-d1b76b48f4364d37bcab8bf18d4ca410
出典データセット
uspto-grants-2014_12
特許番号
US08907093B2

反応ノート

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