2-(4-Fluorophenyl)acetyl isothiocyanate → N-(3-Fluoro-4-(2-(5-formylpyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-(4-fluorophenyl)acetamide

To a solution of 2 (5.27 g, 27.0 mmol) in toluene (50.0 mL) and ethanol (50.0 mL) was added a suspension of intermediate 31 (9.52 g, 22.5 mmol) in toluene (20 mL) and ethanol (20 mL) over 30 min. After few minutes, more of isothiocyanate (1 g) in ethanol/toluene (5 mL/5 mL) mixture was added over 1 min. The reaction mixture was stirred at r.t. for an additional 30 min and concentrated under reduced pressure. The residue was triturated with toluene (70 mL), filtered and washed with toluene (20 mL) to afford a beige solid material that was suspended in 80% acetic acid (204 mL) and heated at 90° C. overnight. The reaction mixture was cooled down to r.t., and the precipitate was collected by filtration, washed with 80% AcOH (2×30 mL) to afford compound 33 (8.24 g, 72% yield) as a yellow solid.

1. waitAfter few minutes
2. concentrationconcentrated under reduced pressure
3. customThe residue was triturated with toluene (70 mL)
4. filtrationfiltered
5. washwashed with toluene (20 mL)
6. customto afford a beige solid material that
7. temperatureheated at 90° C. overnight
8. temperatureThe reaction mixture was cooled down to r.t.
9. filtrationthe precipitate was collected by filtration
10. washwashed with 80% AcOH (2×30 mL)

ORDレコード

ord-0c3a27cab41a49b9b09a47b5ae9ea9bd

出典データセット

uspto-grants-2014_12

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08907091B2