1-Chloro-4-(2,2-dibromoethenyl)benzene → 1-(Bromoethynyl)-4-chlorobenzene

HRID 1401678ノート

反応式

HRID 1401678 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[C:9](Br)[Br:10])=[CH:4][CH:3]=1.CC(C)([O-])C.[K+]>C1(C)C=CC=CC=1.O>[Br:10][C:9]#[C:8][C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1

参加物

5

反応物 2

HCID 64229811-Chloro-4-(2,2-dibromoethenyl)benzeneHCID 23665647Potassium tert-butoxide

生成物 1

HCID 6403901-(Bromoethynyl)-4-chlorobenzene収率 78.1%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1140Toluene溶媒

反応条件

温度
80 °C

実験手順

To a solution of 1-chloro-4-(2,2-dibromovinyl)benzene (9.60 g, 32.7 mmol) in toluene was added potassium tertbutoxide (7.35 g, 65.6 mmol) at RT. The reaction mixture was heated at 80° C. for 3 h. The reaction was monitored by LCMS and TLC. The reaction mixture was diluted with water and extracted with EtOAc. The organic was dried over sodium sulfate and concentrated under reduced pressure to give the desired product (5.5 g).

後処理

  1. extractionextracted with EtOAc
  2. dry with materialThe organic was dried over sodium sulfate
  3. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-bc8917bf143d41c78140bb46a2344004
出典データセット
uspto-grants-2014_12
特許番号
US08907097B2

反応ノート

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