4,4-Dimethyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydronaphthalen-1(2H)-one → 7-{2-[4-(2-hydroxyethylamino)piperidin-1-yl]thiazol-4-yl}-4,4-dimethyl-3,4-dihydro-2H-naphthalen-1-one

HRID 1401775ノート

反応式

HRID 1401775 の反応式
Br[C:2]1[N:3]=[C:4]([N:7]2[CH2:12][CH2:11][CH:10]([NH:13][CH2:14][CH2:15][OH:16])[CH2:9][CH2:8]2)[S:5][CH:6]=1.[CH3:17][C:18]1([CH3:38])[C:27]2[C:22](=[CH:23][C:24](B3OC(C)(C)C(C)(C)O3)=[CH:25][CH:26]=2)[C:21](=[O:37])[CH2:20][CH2:19]1>>[OH:16][CH2:15][CH2:14][NH:13][CH:10]1[CH2:11][CH2:12][N:7]([C:4]2[S:5][CH:6]=[C:2]([C:24]3[CH:23]=[C:22]4[C:27]([C:18]([CH3:38])([CH3:17])[CH2:19][CH2:20][C:21]4=[O:37])=[CH:26][CH:25]=3)[N:3]=2)[CH2:8][CH2:9]1

参加物

3

反応物 2

HCID 673232734,4-Dimethyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydronaphthalen-1(2H)-oneHCID 673233402-(1-(4-Bromothiazol-2-yl)piperidin-4-ylamino)ethanol

生成物 1

HCID 673769197-{2-[4-(2-hydroxyethylamino)piperidin-1-yl]thiazol-4-yl}-4,4-dimethyl-3,4-dihydro-2H-naphthalen-1-one

実験手順

The preparation is carried out as already described above starting from 100 mg (0.27 mmol) of 2-[1-(4-bromothiazol-2-yl)piperidin-4-ylamino]ethanol (preparation already described above) and 88 mg (0.29 mmol) of 4,4-dimethyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-naphthalen-1-one. The product was purified by means of flash chromatography on silica gel.

後処理

  1. custompreparation
  2. customThe product was purified by means of flash chromatography on silica gel

出典と根拠

ORDレコード
ord-22ed3085e3eb4814aa37e581afddd375
出典データセット
uspto-grants-2014_12
特許番号
US08907098B2

反応ノート

読み込み中…