反応式
Br[CH2:2][C:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:11]([CH3:16])([CH3:15])[CH2:10][CH2:9][C:8]([CH3:18])([CH3:17])[C:7]=2[CH:6]=1)=O.[OH:19][CH2:20][CH2:21][CH2:22][CH2:23][NH:24][CH:25]1[CH2:31][CH2:30][CH2:29][N:28]([C:32](=[S:34])[NH2:33])[CH2:27][CH2:26]1>>[CH3:15][C:11]1([CH3:16])[CH2:10][CH2:9][C:8]([CH3:17])([CH3:18])[C:7]2[CH:6]=[C:5]([C:3]3[N:33]=[C:32]([N:28]4[CH2:29][CH2:30][CH2:31][CH:25]([NH:24][CH2:23][CH2:22][CH2:21][CH2:20][OH:19])[CH2:26][CH2:27]4)[S:34][CH:2]=3)[CH:14]=[CH:13][C:12]1=2参加物
3
実験手順
The preparation is carried out as already described starting from 508 mg (1.15 mmol) of 2-bromo-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethanone and the product from step c. The purification was carried out by means of preparative HPLC. The product is in the form of the hydrochloride.
後処理
- customThe purification
出典と根拠
- ORDレコード
- ord-288bc318ac094b09baa7444ed4b7929f
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08907098B2
関連ノート
読み込み中…