Water → HCID 67323440、化合物

HRID 1401851ノート

反応式

HRID 1401851 の反応式
Br[C:2]1[S:3][CH:4]=[C:5]([Br:7])[N:6]=1.Cl.[NH:9]1[CH2:14][CH2:13][C:12](=[O:15])[CH2:11][CH2:10]1.C(N(CC)CC)C.O>CN(C=O)C>[Br:7][C:5]1[N:6]=[C:2]([N:9]2[CH2:14][CH2:13][C:12](=[O:15])[CH2:11][CH2:10]2)[S:3][CH:4]=1

参加物

6

反応物 4

HCID 962WaterHCID 8471TriethylamineHCID 27632972,4-Dibromo-1,3-thiazoleHCID 30848514-Piperidone hydrochloride

生成物 1

HCID 67323440HCID 67323440、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
80 °C

実験手順

1 g (4.12 mmol) of 2,4-dibromothiazole was dissolved in 10 ml of DMF, 1.06 g (7.82 mmol) of piperidin-4-one hydrochloride and 2.3 ml (16.47 mmol) of triethylamine were added, and the mixture was stirred at 80° C. for 3 days. The reaction mixture was stirred into 300 ml of water and extracted by shaking with EA. The organic phase was dried over sodium sulfate, filtered and evaporated. The purification was carried out by means of flash chromatography on silica gel.

後処理

  1. extractionextracted
  2. stirringby shaking with EA
  3. dry with materialThe organic phase was dried over sodium sulfate
  4. filtrationfiltered
  5. customevaporated
  6. customThe purification

出典と根拠

ORDレコード
ord-9a24ae5764b64fbcb5974be2df6fb266
出典データセット
uspto-grants-2014_12
特許番号
US08907098B2

反応ノート

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