戻る
化工社化工社 化学情報印刷レポート · 研究参考用
HRID 14026作成日：2026年10月26日

3-Carbamoyl-5-dipropylcarbamoyl-benzoic acid → N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-(hydroxymethyl)-N3,N3-dipropylisophthalamide

https://huagongshe.com/reaction/14026

反応式

関与物質

役割名称HCID仕込み量
反応物3-Carbamoyl-5-dipropylcarbamoyl-benzoic acidHCID 22394891—
反応物(2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-[(3-methoxybenzyl)amino]-2-butanol TrifluoroacetateHCID 69869154—
生成物N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-(hydroxymethyl)-N3,N3-dipropylisophthalamideHCID 68610888—

反応手順

Following the procedure of CHART P and Example 739 and making non-critical variations but using 3-[(dipropylamino)carbonyl]-5-(hydroxymethyl)benzoic acid (IX) and (2R,3S)-3-amino-1-[(3-methoxybenzyl)amino]-4-phenyl-2-butanol (VIII), the title compound is obtained, HRMS (FAB)=615.3571.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07727997B2
出典データセットuspto-grants-2010_06
ORD IDord-d7129d6dce2e450d859df2905d292e8c
出典メモuspto-grants-2010_06