関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | N-(2-acetyl-4-bromophenyl)acetamide | HCID 459291 | — |
| 反応物 | Ammonium Acetate | HCID 517165 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 6-Bromo-2,4-dimethylquinazoline | HCID 58329327 | 23.4% |
反応手順
415 mg N-(2-acetyl-4-bromophenyl)acetamide and 0.624 g of ammonium acetate was dissolved in 5 mL of glacial acetic acid and heated for 2 days at 100° C. The solvent was removed and the residue suspended in water and extracted with DCM. The organic phase was concentrated and purified via FCC (25 g SiO2, DCM:MeOH 100:0→70:30) to yield 90 mg of 6-bromo-2,4-dimethylquinazoline as oil. Analysis: HPLC-MS: Rt=1.26 min (method V003—003), M+H=237/239.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08912173B2 |
|---|
| 出典データセット | uspto-grants-2014_12 |
|---|
| ORD ID | ord-8a7033eb63044ca2be9855fcfbe6a4ac |
|---|
| 出典メモ | uspto-grants-2014_12 |
|---|
