3-(4-Chlorophenyl)-1-(2-fluorophenyl)propan-1-one → HCID 131732157、化合物

反応式

ClC1C=CC(CCC(C2C=CC=CC=2F)=O)=CC=1.[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][CH2:27]/[C:28](/[C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=2[F:41])=[CH:29]/[C:30]([O:32][CH2:33][CH3:34])=[O:31])=[CH:22][CH:21]=1>>[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][CH2:27]/[C:28](/[C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=2[F:41])=[CH:29]\[C:30]([O:32][CH2:33][CH3:34])=[O:31])=[CH:22][CH:21]=1

参加物

反応物 2

HCID 247260933-(4-Chlorophenyl)-1-(2-fluorophenyl)propan-1-one

HCID 131732158HCID 131732158、化合物

生成物 1

HCID 131732157HCID 131732157、化合物

実験手順

By a procedure similar to that of example 1.85.3, starting from 3-(4-chlorophenyl)-1-(2-fluorophenyl)propan-1-one, (Z)-ethyl 5-(4-chlorophenyl)-3-(2-fluorophenyl)pent-2-enoate and (E)-ethyl 5-(4-chlorophenyl)-3-(2-fluorophenyl)pent-2-enoate were obtained as colourless oils.

出典と根拠

ORDレコード: ord-89a65f5a302b4897b143679febbc7217
出典データセット: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08912186B2

反応ノート

読み込み中…