関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | Stannous chloride dihydrate | HCID 61436 | — |
| 反応物 | 4-Bromo-N-methyl-2-nitroaniline | HCID 258042 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-Bromo-N1-methylbenzene-1,2-diamine | HCID 11298593 | 96% |
反応手順
To a solution of 4-bromo-N-methyl-2-nitroaniline (6 g, 25.97 mmol) in ethanol (100 ml) was added SnCl2.2H2O (29 g, 128.52 mmol). The resulting solution was stirred for 3 h at 70° C., adjusted to pH 8 with potassium hydroxide (4M), extracted with ethyl acetate (2×200 ml), and the organic layers combined and concentrated under vacuum to afford 4-bromo-N1-methylbenzene-1,2-diamine as a white solid (5 g, 96%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08912188B2 |
|---|
| 出典データセット | uspto-grants-2014_12 |
|---|
| ORD ID | ord-4f18281862d04755845e3e6fb994d053 |
|---|
| 出典メモ | uspto-grants-2014_12 |
|---|
