2-(4-(benzyloxy)-7-bromo-5-fluoro-1-methyl-1H-indol-3-yl)acetic acid → 2-(6-bromo-7-propyl-3,7-dihydro-2H-[1,4]dioxino[2,3-e]indol-9-yl)acetic acid

反応式

C(OC1C(F)=CC(Br)=C2C=1C([CH2:21][C:22]([OH:24])=[O:23])=CN2C)C1C=CC=CC=1.[Br:25][C:26]1[CH:27]=[C:28]2[O:41][CH2:40][CH2:39][O:38][C:29]2=[C:30]2[C:34]=1[N:33]([CH2:35][CH2:36][CH3:37])[CH:32]=[CH:31]2>>[Br:25][C:26]1[CH:27]=[C:28]2[O:41][CH2:40][CH2:39][O:38][C:29]2=[C:30]2[C:34]=1[N:33]([CH2:35][CH2:36][CH3:37])[CH:32]=[C:31]2[CH2:21][C:22]([OH:24])=[O:23]

参加物

反応物 2

HCID 583040362-(4-(benzyloxy)-7-bromo-5-fluoro-1-methyl-1H-indol-3-yl)acetic acid

HCID 669272196-bromo-7-propyl-3,7-dihydro-2H-[1,4]dioxino[2,3-e]indole

生成物 1

HCID 669273212-(6-bromo-7-propyl-3,7-dihydro-2H-[1,4]dioxino[2,3-e]indol-9-yl)acetic acid収率 74%

実験手順

Following the procedure (step 3, scheme 333) used to prepare compound 33-4, compound 40-3 gave compound 40-4 in 74% yield as a yellow solid. LCMS: calc 353.0 found 353.9 [MH]+.

出典と根拠

ORDレコード: ord-3286cd95e0a848d9a8a3e2ce719621ac
出典データセット: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08912220B2

反応ノート

読み込み中…