関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethyl 2-(1,4-dioxaspiro[4.5]decan-8-yl)acetate | HCID 15700391 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 2-(1,4-Dioxaspiro(4.5)decan-8-yl)ethan-1-ol | HCID 11805458 | 102.2% |
反応手順
To a solution of ethyl 2-(1,4-dioxaspiro[4.5]decan-8-yl)acetate from Step 1 (3.31 g, 14.5 mmol) in Et2O (80 mL) at 0° C. under N2 was added LiAlH4 (1M in THF, 13.66 mL, 13.66 mmol) in 15 min. The resulting mixture was stirred at 0° C. for another 20 min and quenched by addition of saturated aqueous NH4Cl solution, extracted with EtOAc, dried over Na2SO4. Filtration and evaporation to dryness gave the alcohol as white solid (2.76 g, 100%). LC/MC: 187.1 (MH)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08912169B2 |
|---|
| 出典データセット | uspto-grants-2014_12 |
|---|
| ORD ID | ord-590d9d7fa83f48b487923e4be701d69d |
|---|
| 出典メモ | uspto-grants-2014_12 |
|---|
