3-(2-Dimethylaminoethylaminocarbonyl)benzeneboronic acid → 3-{1-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1H-pyrrolo[3,2-b]pyridin-6-yl}-N-[2-(dimethylamino)ethyl]benzamide
反応式
Br[C:2]1[CH:3]=[C:4]2[N:10]([O:11][CH:12]([C:14]3[C:19]([Cl:20])=[CH:18][CH:17]=[C:16]([F:21])[C:15]=3[Cl:22])[CH3:13])[CH:9]=[CH:8][C:5]2=[N:6][CH:7]=1.[CH3:23][N:24]([CH3:39])[CH2:25][CH2:26][NH:27][C:28]([C:30]1[CH:31]=[C:32](B(O)O)[CH:33]=[CH:34][CH:35]=1)=[O:29]>>[Cl:22][C:15]1[C:16]([F:21])=[CH:17][CH:18]=[C:19]([Cl:20])[C:14]=1[CH:12]([O:11][N:10]1[C:4]2[C:5](=[N:6][CH:7]=[C:2]([C:34]3[CH:35]=[C:30]([CH:31]=[CH:32][CH:33]=3)[C:28]([NH:27][CH2:26][CH2:25][N:24]([CH3:39])[CH3:23])=[O:29])[CH:3]=2)[CH:8]=[CH:9]1)[CH3:13]参加物
3
実験手順
The entitled compound was prepared from 6-bromo-1-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1H-pyrrolo[3,2-b]pyridine and (3-{[2-(dimethylamino)ethyl]carbamoyl}phenyl)boronic acid according to the procedure described in example 4.
出典と根拠
- ORDレコード
- ord-499bc06155f14c31b6f5412cc3e1f4c7
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08912330B2
反応ノート
読み込み中…