Hydrochloric Acid → 2-{Benzyl-[2-(4-benzyloxyphenyl)-ethyl]-amino}-1-(4-hydroxy-phenyl)-propan-1-one hydrochloride

HRID 1404694ノート

反応式

HRID 1404694 の反応式
[CH2:1]([N:8]([CH2:20][CH2:21][C:22]1[CH:27]=[CH:26][C:25]([O:28][CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[CH:24][CH:23]=1)[CH:9]([CH3:19])[C:10]([C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=1)=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:36]>CC(=O)CC>[ClH:36].[CH2:1]([N:8]([CH2:20][CH2:21][C:22]1[CH:23]=[CH:24][C:25]([O:28][CH2:29][C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)=[CH:26][CH:27]=1)[CH:9]([CH3:19])[C:10]([C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=1)=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 545759581-(4-Hydroxyphenyl)-2-[[2-[4-(phenylmethoxy)phenyl]ethyl](phenylmethyl)amino]-1-propanone

生成物 1

HCID 545759592-{Benzyl-[2-(4-benzyloxyphenyl)-ethyl]-amino}-1-(4-hydroxy-phenyl)-propan-1-one hydrochloride収率 95%

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒2 回

反応条件

温度
50 °C

実験手順

20 g of 2-{Benzyl-[2-(4-benzyloxyphenyl)-ethyl]-amino}-1-(4-hydroxy-phenyl)-propan-1-one and 100 ml of methyl ethyl ketone are introduced into a 250 ml reactor. At 20° C., 9 g of a solution with 19% by weight of HCl in 2-butanone are added. Once the precipitation of the solid has occurred, it is heated to 50° C. and it is diluted with 40 ml of methyl ethyl ketone. It is kept under stirring for an hour and then it is cooled down again to 20° C. The solid is filtered and is washed with 80 ml of methyl ethyl ketone. After vacuum drying at 40° C., 20.6 g of 2-{Benzyl-[2-(4-benzyloxyphenyl)-ethyl]-amino}-1-(4-hydroxy-phenyl)-propan-1-one hydrochloride as a white solid, are obtained.

後処理

  1. customOnce the precipitation of the solid
  2. additionit is diluted with 40 ml of methyl ethyl ketone
  3. temperatureit is cooled down again to 20° C
  4. filtrationThe solid is filtered
  5. washis washed with 80 ml of methyl ethyl ketone
  6. customAfter vacuum drying at 40° C.

出典と根拠

ORDレコード
ord-72070bf322064cbb978e0405d910afe4
出典データセット
uspto-grants-2014_12
特許番号
US08912360B2

反応ノート

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