HCID 67959087、化合物 → 8-(3-Methoxyphenyl)-2-methyl-2,3,4,5-tetrahydrothieno[2,3-f][1,4]oxazepine

HRID 1404968ノート

反応式

HRID 1404968 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[C:18]3[O:17][CH:16]([CH3:19])[CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][C:12]=3[S:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1>C(OCC)(=O)C.Cl>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[C:18]3[O:17][CH:16]([CH3:19])[CH2:15][NH:14][CH2:13][C:12]=3[S:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1

参加物

3

反応物 1

HCID 67959087HCID 67959087、化合物

生成物 1

HCID 679591608-(3-Methoxyphenyl)-2-methyl-2,3,4,5-tetrahydrothieno[2,3-f][1,4]oxazepine収率 104.5%

試薬・触媒・溶媒 1

HCID 21866389Hydrogen chloride-ethyl acetate溶媒

実験手順

tert-Butyl 8-(3-methoxyphenyl)-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepine-4(5H)-carboxylate (287 mg) was stirred in 4 N hydrogen chloride-ethyl acetate solution (5 mL) for 30 min. The reaction solution was concentrated under reduced pressure, and the residue was recrystallized from ethyl acetate to give 8-(3-methoxyphenyl)-2-methyl-2,3,4,5-tetrahydrothieno[2,3-f][1,4]oxazepine 1 hydrochloride (220 mg, 92%) as colorless crystals.

後処理

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. customthe residue was recrystallized from ethyl acetate

出典と根拠

ORDレコード
ord-c75567506de947e88348ddd6dc8d14c4
出典データセット
uspto-grants-2014_12
特許番号
US08916549B2

反応ノート

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